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Chemical Data

Full Chemical Name: UR-144
Systematic IUPAC Name: (1-pentylindol-3-yl)-(2,2,3,3-tetramethylcyclopropyl)methanone
CAS Number: 1199943-44-6
ChemSpider Number: 24634882
Molecular Formula: C21H29NO
Molecular Mass: 311.461 g/mol

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  • UR-144


What is UR-144?
Developed by Abbott Laboratories, UR-144 is another member of the Synthetic Cannabinoid research chemical family. Also known by the names TMCP-018, KM-X1, MN-001 and YX-17 this cannabinoid exhibits full agonist activity to the peripheral cannabinoid receptor CB1 with high selectivity. Many researchers have found that UR-144 is an excellent chemical to compliment studies with AM-2201, MAM-2201 and other synthetic cannabinoids due to its similar binding. It has proven very popular so far with great feedback from current in vitro (outside living organism) studies.

What is UR-144 used for?
It has unique properties in that it binds with a high selectivity for the peripheral CB2 receptor which would make it a great candidate for in vitro profiling of its efficacy with this receptor. Synthetic membranes with infused CB2 receptors could be used to study the affinity and even competitive ligand binding with other CB2 agonists. So far, studies have shown a Ki of 1.8nM for the CB2 with an affinity for the CB1 being 150nM. Some studies utilise the vapour from UR-144 heat combustion to allow for a thin evenly distributed aerosol to be applied to mediums. UR-144 is licenced for in vitro research only unless a home office licence is obtained stating otherwise. Certain laboratories specialise in compiling chemical analysis libraries of novel chemicals. UR-144 maybe analysed using FTIR, NMR, HPLC or GC/MS techniques and added to these libraries. It may also find a use as a primary reagent for any chemistry research programme.

For more information on UR-144, please view the Wikipedia page by click here

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