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Chemical Data

Full Chemical Name: MDAI
Systematic IUPAC Name: 6,7-dihydro-5H-cyclopenta[f][1,3]benzodioxol-6-amine
CAS Number: 132741-81-2
ChemSpider Number: 111694
Molecular Formula: C10H11NO2
Molecular Mass: 177.1998 g/mol


  • MDAI


What is MDAI?
5,6-Methylenedioxy-2-aminoidane or abbreviated to MDAI is a research chemical first synthesised in the 1990’s by David E Nichols and his team. During in vitro (outside living organism) testing it acts as a non-neurotoxic selective serotonin releasing agent (SSRA). Due to this type of action upon receptors, if ever licenced to human research it would most probably fall into the Entactotogen class of compound. It is extremely similar in chemical structure to MDA however the alpha-methyl group of the alkylamino amphetamine side chain has been bound back to the benzene, to form an indane ring. Based on in vtiro studies the structure of it is theorized that it works by actively effecting the serotonin transporter. Many researchers have given excellent feedback on MDAI due to its specific affinity, this is why MDAI has been very difficult to get hold of in the UK due to high demand and depleted stock.

What is MDAI used for?
It inhibits the reuptake of serotonin, dopamine, norepinephrine with IC50 values of 512nM, 5,920nM abd a,426nM, respectively. This means that researchers can use MDAI to effectively study and further understand the mechanism of action involved in serotonin release compared to norepinephrine and dopamine. MDAI could be placed in a solution, then applied to a receptor infused membrane in vitro to measure its affinity. MDAI could also be used by reference cataloguers for chemical NMR, GC/MS and FTIR analysis. Chemistry students can use MDAI as a primary reagent for their experiments.

For more information on MDAI, please view the Wikipedia page by Clicking here.

As with all our research chemicals, MDAI is strictly not for human consumption or any form of in vivo research. You must be over the age of 18 to purchase from buyanychem. By purchasing our chemicals, you agree in full to our terms and conditions..